医学
他汀类
危险系数
胃切除术
癌症
内科学
阶段(地层学)
置信区间
人口
外科
比例危险模型
流行病学
胃肠病学
生物
环境卫生
古生物学
作者
Dong Hyuk Nam,Hyuk Lee,Jun Chul Park,Sung Kwan Shin,Sang Kil Lee,Woo Jin Hyung,Yong Chan Lee,Min Ji Kang,Sung Hoon Noh
出处
期刊:PubMed
日期:2014-01-01
卷期号:34 (1): 355-61
被引量:10
摘要
Although several epidemiological studies have indicated that statins may have antitumor properties, the effect of statins on patient survival after curative resection of gastric cancer is unknown. The aim of the present study was to determine whether statin use could improve long-term outcomes after radical gastrectomy. PATIENS AND METHODS: We conducted a matched case-control study of 65 statin users and 176 non-users who underwent radical gastrectomy for stage II and III gastric cancer from January 2006 to December 2009.No significant differences were found in recurrence-free survival (RFS) or overall survival (OS) between statin users and non-users. However, subgroup analysis showed that patients who used statins for more than six months had more favorable outcomes than non-users or those who used statins for less than six months [adjusted hazard ratio of death (non-users as reference); statin use <6 months: 2.405, 95% confidence interval (CI)=1.056-5.477 and statin use >6 months: 0.168, 95% CI=0.032-0.881, p=0.006].Statin use did not improve RFS or OS after curative resection of stage II or III gastric cancer in the overall study population. However, statin use of more than six months was associated with increased survival.
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