动力学分辨率
化学
对映体药物
基质(水族馆)
分辨率(逻辑)
离子液体
有机化学
对映选择合成
立体化学
催化作用
海洋学
人工智能
地质学
计算机科学
作者
Maria‐Concepción Gutiérrez,R. Furstoss,Véronique Alphand
标识
DOI:10.1002/adsc.200505048
摘要
Abstract A dynamic kinetic resolution process was applied to an enantioconvergent microbial Baeyer–Villiger oxidation of benzyloxycyclopentanone, rac ‐ 1 . This was achieved by combining a whole cell‐based kinetic resolution and an anion exchange resin‐catalysed in situ racemisation. Several resins were screened according to their capacity to catalyse the racemisation of 1 . As compared to our previous results, the presence of weakly basic Lewatit MP62 in biotransformations of 1 allowed a three‐fold improvement of usable substrate concentration and afforded nearly enantiopure lactone ( R )‐ 2 (97% ee) in preparative (isolated) yields higher than 84%. Noyori's model was applied to this reaction and allowed kinetic constants determination.
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