2H14 Effects of remodeling signals on bone functional adaptation

Bone remodels its structure to functionally adapt to its mechanical environment. Bone cells produce signaling molecules activated by mechanical stimuli. It is considered that remodeling signals regulate bone remodeling. RANK, RANKL and OPG are well known as remodeling signals. RANKL promotes osteoclastogenesis by binding to RANK, while OPG acts as a decoy receptor by binding to RANKL. In this study, we proposed mathematical models of trabecular bone remodeling combining mechanosensing and remodeling signals, and conducted computational simulation. Focusing on the active bone remodeling area, we discussed the effects of remodeling signals on the functional adaptation capacity of trabeculae. We found that, under the condition where RANKL and OPG expressions balance each other, the active remodeling area is larger when both of the rates are higher.