Alphaherpesvirus UL48 homologs degrade STING1 by selective autophagy

: 3-MA: 3-methyladenine; B-DNA: poly (dA:dT); BNIP3L/Nix: BCL2 interacting protein 3 like; CALCOCO2/NDP52: calcium binding and coiled-coil domain 2; cGAMP: cyclic GMP-AMPP; CGAS: cyclic GMP-AMP synthase; CHX: cyclohexane; CHV-2: cercopithecine herpesvirus 2; CQ: chloroquine; DAPI: 4',6-diamidino-2-phenylindole; DMSO: dimethyl sulfoxide; ER: endoplasmic reticulum; GFP: green fluorescent protein; H&E: hematoxylin and eosin; HSV-1: herpes simplex virus 1; IRF3: interferon regulatory factor 3; LIR: LC3-interacting region; MAP1LC3A/LC3: microtubule associated protein 1 light chain 3 alpha; MG132: cbz-leu-leu-leucinal; NBR1: NBR1 autophagy cargo receptor; OPTN: optineurin; PRV: pseudorabies virus; sgRNA: single guide RNA; siRNA: small interfering RNA; SQSTM1/p62: sequestosome 1; STING1/STING: stimulator of interferon response cGAMP interactor 1; TBK1: TANK binding kinase 1; TOLLIP: toll interacting protein.