生物
细胞骨架
细胞生物学
微管
焦点粘着
串扰
微丝
肌动蛋白
中间灯丝
细胞迁移
电池极性
细胞
肌动蛋白重塑
肌动蛋白细胞骨架
信号转导
遗传学
光学
物理
作者
Shailaja Seetharaman,Sandrine Etienne-Manneville
标识
DOI:10.1016/j.tcb.2020.06.004
摘要
Cell migration is a highly dynamic process driven by the cytoskeleton, which mainly comprises the actin microfilaments, microtubules, and intermediate filaments. During migration, cells polarize and form protrusions at the front, where new adhesions are formed. These nascent adhesions mature into focal adhesions that transmit the traction forces required for movement. All of these steps are coupled to major cytoskeletal rearrangements and are controlled by a wide array of signaling cascades. The constant crosstalk between actin, microtubules, and intermediate filaments ensures their coordinated dynamics to facilitate cell migration. Here, we first describe how master regulators, such as RhoGTPases, can simultaneously control the three cytoskeletal structures. We then summarize the recent crosstalk mechanisms by which cytoskeletal networks can locally regulate one another in order to function in a coordinated and efficient manner during migration.
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