肝细胞癌
生物标志物
价值(数学)
医学
内科学
肿瘤科
癌
生物
数学
统计
遗传学
作者
Shao-Lan Qin,Huanhuan Zhou,Na Xu,Huan Yang,P X Chen
出处
期刊:Clinical Laboratory
[Clinical Laboratory Publications]
日期:2020-01-01
卷期号:66 (12/2020)
被引量:8
标识
DOI:10.7754/clin.lab.2020.200231
摘要
Background Long noncoding RNA (lncRNA) is a promising serum biomarker in cancer diagnosis. However, literature on the diagnostic value of the lncRNA for hepatocellular carcinoma (HCC) is scant. Methods The expression of ST8SIA6-AS1 in serum and HCC cell lines was detected by real-time PCR (RT-PCR). We then analyzed the relationship between clinicopathological characteristics and serum ST8SIA6-AS1 expression. In addition, we performed the receiver operating characteristic (ROC) curve and area under curve (AUC) analyses to determine the diagnostic ability of serum ST8SIA6-AS1. Results Our data demonstrated an up-regulation of ST8SIA6-AS1 in 77 HCC patients and HCC cell lines. Besides, clinicopathological analysis revealed that ST8SIA6-AS1 corresponds with tumor stages and metastasis, thus might be used for monitoring the HCC progress. Importantly, the ROC analysis demonstrated that ST8SIA6-AS1 yields a superior diagnostic ability. Compared with α-fetoprotein (AFP) alone, a combination of ST8SIA6-AS1 and AFP may achieve more reliable diagnostic results. Conclusions Together, our results demonstrate that serum ST8SIA6-AS1 is a promising serum diagnostic bio-marker for HCC.
科研通智能强力驱动
Strongly Powered by AbleSci AI