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SM17, a new IL‐17RB‐targeting antibody, ameliorates disease progression in a mouse model of atopic dermatitis

特应性皮炎 医学 传统医学 免疫学
作者
Linda Lam,Weimin Liu,Wai Chung Wu,Kai Cheung Chow,Wing Y. Au,Guolin Xu,Guojian Wei,Xuchen Qian,Ka Man Ng,Shaik Abdullah Nawabjan,Muthu Iswarya Gandhi Sethuraman,Wai Yan Choi,Billy K. C. Chow,Shui On Leung,Chin Wai Hui
出处
期刊:Allergy [Wiley]
标识
DOI:10.1111/all.16120
摘要

AllergyEarly View LETTER SM17, a new IL-17RB-targeting antibody, ameliorates disease progression in a mouse model of atopic dermatitis Lik Hang Lam, Lik Hang Lam SinoMab BioScience Limited, Hong Kong, ChinaSearch for more papers by this authorWeimin Li, Weimin Li SinoMab BioScience Limited, Hong Kong, ChinaSearch for more papers by this authorWai Chung Wu, Wai Chung Wu SinoMab BioScience Limited, Hong Kong, ChinaSearch for more papers by this authorKai Cheung Chow, Kai Cheung Chow SinoMab BioScience Limited, Hong Kong, ChinaSearch for more papers by this authorWai Yin Dennis Au, Wai Yin Dennis Au SinoMab BioScience Limited, Hong Kong, ChinaSearch for more papers by this authorGuolin Xu, Guolin Xu MediNexus Pharma (Suzhou) Limited, Suzhou, Jiangsu, ChinaSearch for more papers by this authorGe Wang, Ge Wang MediNexus Pharma (Suzhou) Limited, Suzhou, Jiangsu, ChinaSearch for more papers by this authorXuchen Qian, Xuchen Qian orcid.org/0000-0003-3049-7655 MediNexus Pharma (Suzhou) Limited, Suzhou, Jiangsu, ChinaSearch for more papers by this authorKa Man Ng, Ka Man Ng School of Biological Sciences, The University of Hong Kong, Hong Kong, ChinaSearch for more papers by this authorShaik Abdullah Nawabjan, Shaik Abdullah Nawabjan School of Biological Sciences, The University of Hong Kong, Hong Kong, ChinaSearch for more papers by this authorMuthu Iswarya Gandhi Sethuraman, Muthu Iswarya Gandhi Sethuraman School of Biological Sciences, The University of Hong Kong, Hong Kong, ChinaSearch for more papers by this authorWai Yan Choi, Wai Yan Choi School of Biological Sciences, The University of Hong Kong, Hong Kong, ChinaSearch for more papers by this authorBilly Kwok Chong Chow, Billy Kwok Chong Chow School of Biological Sciences, The University of Hong Kong, Hong Kong, ChinaSearch for more papers by this authorShui On Leung, Shui On Leung SinoMab BioScience Limited, Hong Kong, ChinaSearch for more papers by this authorChin Wai Hui, Corresponding Author Chin Wai Hui [email protected] orcid.org/0000-0002-0787-2624 SinoMab BioScience Limited, Hong Kong, China Correspondence Chin Wai Hui, SinoMab BioScience Limited, Units 303 and 305 to 307, No. 15 Science Park West Avenue, Hong Kong Science Park, Pak Shek Kok, New Territories, Hong Kong, China. Email: [email protected]Search for more papers by this author Lik Hang Lam, Lik Hang Lam SinoMab BioScience Limited, Hong Kong, ChinaSearch for more papers by this authorWeimin Li, Weimin Li SinoMab BioScience Limited, Hong Kong, ChinaSearch for more papers by this authorWai Chung Wu, Wai Chung Wu SinoMab BioScience Limited, Hong Kong, ChinaSearch for more papers by this authorKai Cheung Chow, Kai Cheung Chow SinoMab BioScience Limited, Hong Kong, ChinaSearch for more papers by this authorWai Yin Dennis Au, Wai Yin Dennis Au SinoMab BioScience Limited, Hong Kong, ChinaSearch for more papers by this authorGuolin Xu, Guolin Xu MediNexus Pharma (Suzhou) Limited, Suzhou, Jiangsu, ChinaSearch for more papers by this authorGe Wang, Ge Wang MediNexus Pharma (Suzhou) Limited, Suzhou, Jiangsu, ChinaSearch for more papers by this authorXuchen Qian, Xuchen Qian orcid.org/0000-0003-3049-7655 MediNexus Pharma (Suzhou) Limited, Suzhou, Jiangsu, ChinaSearch for more papers by this authorKa Man Ng, Ka Man Ng School of Biological Sciences, The University of Hong Kong, Hong Kong, ChinaSearch for more papers by this authorShaik Abdullah Nawabjan, Shaik Abdullah Nawabjan School of Biological Sciences, The University of Hong Kong, Hong Kong, ChinaSearch for more papers by this authorMuthu Iswarya Gandhi Sethuraman, Muthu Iswarya Gandhi Sethuraman School of Biological Sciences, The University of Hong Kong, Hong Kong, ChinaSearch for more papers by this authorWai Yan Choi, Wai Yan Choi School of Biological Sciences, The University of Hong Kong, Hong Kong, ChinaSearch for more papers by this authorBilly Kwok Chong Chow, Billy Kwok Chong Chow School of Biological Sciences, The University of Hong Kong, Hong Kong, ChinaSearch for more papers by this authorShui On Leung, Shui On Leung SinoMab BioScience Limited, Hong Kong, ChinaSearch for more papers by this authorChin Wai Hui, Corresponding Author Chin Wai Hui [email protected] orcid.org/0000-0002-0787-2624 SinoMab BioScience Limited, Hong Kong, China Correspondence Chin Wai Hui, SinoMab BioScience Limited, Units 303 and 305 to 307, No. 15 Science Park West Avenue, Hong Kong Science Park, Pak Shek Kok, New Territories, Hong Kong, China. Email: [email protected]Search for more papers by this author First published: 09 April 2024 https://doi.org/10.1111/all.16120Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Open Research DATA AVAILABILITY STATEMENT The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation. Supporting Information Filename Description all16120-sup-0001-supinfo.docxWord 2007 document , 1.4 MB Appendix S1. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. REFERENCES 1Deng C, Peng N, Tang Y, et al. Roles of IL-25 in type 2 inflammation and autoimmune pathogenesis. Front Immunol. 2021; 12:691559. 10.3389/fimmu.2021.691559 CASPubMedWeb of Science®Google Scholar 2Salimi M, Barlow JL, Saunders SP, et al. A role for IL-25 and IL-33-driven type-2 innate lymphoid cells in atopic dermatitis. J Exp Med. 2013; 210(13): 2939-2950. 10.1084/jem.20130351 CASPubMedWeb of Science®Google Scholar 3Wu L, Zepp JA, Qian W, et al. A novel IL-25 signaling pathway through STAT5. J Immunol. 2015; 194(9): 4528-4534. 10.4049/jimmunol.1402760 CASPubMedWeb of Science®Google Scholar 4Furue M. Regulation of filaggrin, loricrin, and Involucrin by IL-4, IL-13, IL-17A, IL-22, AHR, and NRF2: pathogenic implications in atopic dermatitis. Int J Mol Sci. 2020; 21(15): 5382. 10.3390/ijms21155382 CASPubMedWeb of Science®Google Scholar 5Kitamura A, Takata R, Aizawa S, Watanabe H, Wada T. A murine model of atopic dermatitis can be generated by painting the dorsal skin with hapten twice 14 days apart. Sci Rep. 2018; 8(1): 5988. 10.1038/s41598-018-24363-6 PubMedGoogle Scholar 6Blauvelt A, Teixeira HD, Simpson EL, et al. Efficacy and safety of upadacitinib vs dupilumab in adults with moderate-to-severe atopic dermatitis: a randomized clinical trial. JAMA Dermatol. 2021; 157(9): 1047-1055. 10.1001/jamadermatol.2021.3023 PubMedWeb of Science®Google Scholar Early ViewOnline Version of Record before inclusion in an issue ReferencesRelatedInformation
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