衣壳
表面等离子共振
化学
效力
苯丙氨酸
分子动力学
单体
人类免疫缺陷病毒（HIV）
代谢稳定性
病毒
立体化学
病毒学
生物物理学
生物
生物化学
体外
纳米技术
纳米颗粒
材料科学
氨基酸
计算化学
有机化学
聚合物
作者
Xiangyi Jiang,Zhen Gao,Prem P. Sharma,Sumit Kumar,Brijesh Rathi,Xiangkai Ji,Jiaojiao Dai,Minghui Xie,Guanyu Dong,Shujing Xu,Erik De Clercq,Christophe Pannecouque,Alexej Dick,Peng Zhan,Xinyong Liu
摘要
The HIV capsid (CA) protein is a promising target for anti-AIDS treatment due to its critical involvement in viral replication. Herein, we utilized the well-documented CA inhibitor PF74 as our lead compound and designed a series of low-molecular-weight phenylalanine derivatives. Among them, compound 7t exhibited remarkable antiviral activity with a high selection index (EC
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