Indium mediated barbier-type allylation: Synthesis of highly functionalized homoallylic difluorohydrins

Indium-mediated Barbier-type allylation of halogenated difluoroacetophenone is reported for the first time. This method can directly and conveniently access homoallylic difluorohydrin alcohol blocks from halogenated difluoroacetophenones, and has good functional group compatibility. As a novel difluoromethylation reagent, the block has potential in the synthesis of fluorinated compounds.