多烯
化学
对映选择合成
催化作用
全合成
试剂
组合化学
级联
立体化学
有机化学
色谱法
作者
Tian-Lu Zheng,Chen-Yu Huo,Wen Bao,Xuetao Xu,Wei-Hao Dai,Fu Cheng,Dong-Sen Duan,Lele Yang,Xiao‐Ming Zhang,Dongsheng Zhu,Shao‐Hua Wang
出处
期刊:Organic Letters
[American Chemical Society]
日期:2023-10-09
卷期号:25 (41): 7476-7480
被引量:4
标识
DOI:10.1021/acs.orglett.3c02417
摘要
A catalytic asymmetric 1,3-acyloxy shift/polyene cyclization cascade has been achieved with good enantioselectivities under the catalysis of the chiral Au(I) reagent. The synthetic utility of this method has been showcased by the catalytic asymmetric total syntheses of (+)-2-ketoferruginol, (+)-fleuryinol B, and (+)-salviol. Notably, the first enantioselective total synthesis of (-)-erythroxylisin A has also been realized in 15 steps.
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