自愈水凝胶
壳聚糖
生物相容性
材料科学
伤口愈合
抗菌活性
伤口敷料
粘附
肉芽组织
极限抗拉强度
丙烯酰胺
高分子化学
化学
复合材料
聚合物
共聚物
外科
有机化学
医学
生物
细菌
冶金
遗传学
作者
Jun Du,Yutong Zhang,Yilin Huang,Zhiwei Qiao,Wenzhi Wang,Maolin Yu,Ling Xu,Jianxiong Xu
标识
DOI:10.1002/marc.202300325
摘要
Abstract Biocompatible chitosan‐based hydrogels have attracted extensive attention in wound dressing due to their human skin‐like tissue characteristics. However, it is a crucial challenge to fabricate chitosan‐based hydrogels with versatile properties, including flexibility, stretchability, adhesivity, and antibacterial activity. In this work, a kind of chitosan‐based hydrogels with integrated functionalities are facilely prepared by solution polymerization of acrylamide (AAm) and sodium p ‐styrene sulfonate (SS) in the presence of quaternized carboxymethyl chitosan (QCMCS). Due to the dual cross‐linking between QCMCS and P(AAm ‐co‐ SS), the optimized QCMCS/P(AAm‐ co ‐SS) hydrogel exhibits tough mechanical properties (0.767 MPa tensile stress and 1100% fracture strain) and moderate tissue adhesion (11.4 kPa). Moreover, biological evaluation in vitro illustrated that as‐prepared hydrogel possesses satisfactory biocompatibility, hemocompatibility, and excellent antibacterial ability (against S. aureus and E. coli are 98.8% and 97.3%, respectively). Then, the hydrogels are tested in a rat model for bacterial infection incision in vivo, and the results show that they can significantly accelerate epidermal regeneration and wound closure. This is due to their ability to reduce the inflammatory response, promote the formation of collagen deposition and granulation tissue. The proposed chitosan‐based antibacterial hydrogels have the potential to be a highly effective wound dressing in clinical wound healing.
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