Effect of lncRNA SNHG22 targeting miR-27b-3p on regulation of glioma progression and prognosis

Glioma is a highly aggressive malignant tumor with high mortality, which is prone to metastasis and recurrence. This study investigated the biological function and related mechanism of action of the long non-coding RNA SNHG22 (lncRNA SNHG22; SNHG22) on glioma cells and its prognostic value. The relative expression levels of SNHG22 and miR-27b-3p in the included glioma patients were detected by real-time quantitative PCR (RT-qPCR). The cell counting kit-8 (CCK-8) proliferation assay and Transwell assay confirmed the effect of knockdown of SNHG22 on the biological function of glioma cells. Luciferase activity characterized the mechanism of SNHG22 targeting miR-27b-3p. Additionally, Kaplan-Meier and multivariate Cox analyses were performed to evaluate the effect of SNHG22 on patient survival. In glioma tissues and cells, compared to normal samples as controls, SNHG22 expression was increased and the expression of miR-27b-3p was decreased. Silencing SNHG22 suppressed the proliferation, migration and invasion levels of glioma cells. SNHG22 directly targets miR-27b-3p to regulate tumor progression. Low expression of SNHG22 was more conducive to the survival of patients than high expression of SNHG22. The lncRNA SNHG22 regulated the progression of glioma by targeting miR-27b-3p, which reflected the prognostic potential of SNHG22 and provided a meaningful theoretical reference for the treatment of glioma patients.