化学
脂环化合物
樟脑
广告
立体化学
体外
结构-活动关系
甲型流感病毒
病毒
生物活性
金刚乙胺
有机化学
生物化学
病毒学
生物
作者
А. С. Соколова,Оlga I. Yarovaya,Dmitry S. Baev,Аndrey V. Shernyukov,Анна А. Штро,Vladimir V. Zarubaev,N. F. Salakhutdinov
标识
DOI:10.1016/j.ejmech.2016.10.035
摘要
A series of camphor derived imines was synthesised and evaluated in vitro for antiviral activity. Theoretical evaluations of ADME properties were also carried out. Most of these compounds exhibited significant activity against the drug-resistant strains of influenza A virus. Especially, compounds 2 (SI = 632) and 3 (SI = 417) presented high inhibition against influenza subtypes A/Puerto Rico/8/34 and A/California/07/09 of H1N1pdm09. Analysis of the structure-activity relationship showed that the activity was strongly dependent on the length of the aliphatic chain: derivatives with a shorter chain possessed higher activity, while the suppressing action of compounds with long aliphatic chains was lower.
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