Harpoon Repair for Mitral Regurgitation: A Case Report

•Primary mitral regurgitation (MR) is commonly due to mitral valve (MV) prolapse.•Off-pump minimally invasive MV repair is an alternative to conventional MV surgery.•This case describes MV repair using the Harpoon TSD-5 device.•The technique facilitates image-guided minimally invasive repair.•Early data suggest the Harpoon procedure is safe and durable and reduces morbidity.