化学
吡啶
立体中心
催化作用
组合化学
级联
铜
两性离子
炔丙基
立体化学
药物化学
有机化学
分子
对映选择合成
色谱法
作者
Tingting Li,Yong You,Ting-Jia Sun,Yanping Zhang,Jian‐Qiang Zhao,Zhen-Hua Wang,Wei‐Cheng Yuan
出处
期刊:Organic Letters
[American Chemical Society]
日期:2022-07-12
卷期号:24 (28): 5120-5125
被引量:13
标识
DOI:10.1021/acs.orglett.2c01959
摘要
A copper-catalyzed decarboxylative cascade cyclization of propargylic cyclic carbonates/carbamates with pyridinium 1,4-zwitterionic thiolates is developed. A range of fused polyheterocyclic compounds are obtained in moderate to good yields with excellent diastereoselectivities. Of particular note is that four new bonds (two C-C, one C-O/N, one C-S) and four new stereocenters could be efficiently embedded into the tetracyclic fused scaffolds in a single step.
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