Structure-guided drug discovery for protein kinases using fragment-based lead identification/lead optimization

Acetylcholine-binding protein (AChBP) from the mollusc Lymnaea stagnalis is at present the only high-resolution model for the ligand-binding domains of the ligand-gated ion channel family, which includes nicotinic acetylcholine, 5HT3, GABAA, GABAC and glycine receptors.