贸易
时尚
受体
信号转导衔接蛋白
细胞生物学
生物
死亡域
信号转导
NF-κB
Fas受体
半胱氨酸蛋白酶8
细胞凋亡
癌症研究
程序性细胞死亡
半胱氨酸蛋白酶
生物化学
作者
Pascal Schneider,Margot Thome,Kim Burns,Jean-Luc Bodmer,Kay Hofmann,Takao Kataoka,Nils Holler,Jürg Tschopp
出处
期刊:Immunity
[Elsevier]
日期:1997-12-01
卷期号:7 (6): 831-836
被引量:637
标识
DOI:10.1016/s1074-7613(00)80401-x
摘要
TRAIL induces apoptosis through two closely related receptors, TRAIL-R1 (DR4) and TRAIL-R2 (DR5). Here we show that TRAIL-R1 can associate with TRAIL-R2, suggesting that TRAIL may signal through heteroreceptor signaling complexes. Both TRAIL receptors bind the adaptor molecules FADD and TRADD, and both death signals are interrupted by a dominant negative form of FADD and by the FLICE-inhibitory protein FLIP. The recruitment of TRADD may explain the potent activation of NF-kappaB observed by TRAIL receptors. Thus, TRAIL receptors can signal both death and gene transcription, functions reminiscent of those of TNFR1 and TRAMP, two other members of the death receptor family.
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