荟萃分析
置信区间
人乳头瘤病毒
医学
头颈部癌
逻辑回归
内科学
头颈部
癌症
肿瘤科
人口学
外科
社会学
作者
Jatin P. Shah,Tom Beech,Tom Nicholson,Iman El-Hariry,Christopher C. McConkey,Vinidh Paleri,Sally Roberts
出处
期刊:Head & neck
[Wiley]
日期:2013-05-01
卷期号:35 (5): 747-755
被引量:597
摘要
Little information has been reported on regional and time trends of human papillomavirus (HPV) prevalence rates of oropharyngeal cancer (OPC) and non-OPC.The study consisted of a systematic review and meta-analysis using random effects logistic regression models.Overall HPV prevalence in OPC (47.7%; 95% confidence interval [CI], 42.9-52.5%) increased significantly over time: from 40.5% (95% CI, 35.1-46.1) before 2000, to 64.3% (95% CI, 56.7-71.3) between 2000 and 2004, and 72.2% (95% CI, 52.9-85.7) between 2005 and 2009 (p < .001). Prevalence increased significantly in North America and Europe, and the significant gap between them that existed before 2000 (50.7% vs 35.3%, respectively, p = .008) has now disappeared (69.7% vs 73.1%, respectively, p = .8). Prevalence in non-OPC (21.8%; 95% CI, 18.9-25.1%) has not increased over time (p = .97).The sharp increase in the proportion of HPV-positive OPC over the last decade has occurred at a faster rate in Europe compared with that in North America. In contrast, the relatively low prevalence of HPV in non-OPC remains unchanged.
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