放射免疫疗法
线性能量转移
毒性
癌症研究
α粒子
化学
医学
内科学
免疫学
物理
离子
有机化学
原子物理学
单克隆抗体
抗体
作者
Jostein Dahle,Nasir Abbas,Øyvind S. Bruland,Roy H. Larsen
出处
期刊:Current Radiopharmaceuticals
[Bentham Science]
日期:2011-10-01
卷期号:4 (4): 321-328
被引量:20
标识
DOI:10.2174/1874471011104040321
摘要
Radioimmunotherapy based on α-particle emitters has excellent properties as a treatment against micrometastatic and disseminated cancers because of the short path length (50 - 80 μm) and high linear energy transfer (∼ 100 keV/ μm). Alpha-particles produce clustered DNA double-strand breaks and highly reactive hydroxyl radicals when hitting biological tissue. Hence, targeted α-particle therapy offers the potential of selective tumor cell killing with low damage to surrounding normal tissue. The ideal applications for targeted α-therapy are in treating neoplastic cells in circulation or when cancer cells are present as free-floating cells or spread along compartment walls. This review will provide a brief overview of the most promising radionuclides for targeted α-therapy and compare their relative biological effectiveness (RBE) and normal tissue toxicity.
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