Objective To investigate the risk factors on postoperative complications of patients in department of ENT. Methods Clinical datas of 376 patients in department of ENT were retrospectively analyzed in the hospital from October 2008 to December 2010. 52 patients had postoperative complications. The single factor analysis and Logistic regression analysis were used for risk factors on postoperative complications of patients in department of ENT. Results By single factor analysis and Logistic regression analysis, infection site (P = 0.000, HR = 14.283, 95.0%CI: 9.365-21.038), operation time (P = 0.000, HR = 13.716, 95.0%CI: 7.147-20.275), the hospitalization time (P = 0.002, HR = 15.208, 95.0%CI: 8.918-24.237), antibiotic use (P = 0.000, HR = 14.054, 95.0%CI: 8.163-21.739), hypertension (P = 0.000, HR = 13.976, 95.0%CI: 7.926-22.385) were risk factors on postoperative complications of patients in department of ENT. Conclusion Control of the major risk factors of postoperative infection and bleeding of patients in department of ENT can significantly improve the prognosis.