Study of sequential therapy on the patients of COPD-AE with methylprednisolone

Objective:To evaluate the clinical course,effect,and drug economy sequential therapy on the patients of COPD-AE with methylprednisolone.Method:We adopted random,parallel,open,control multicentre study.The 116 patients of severe COPD-AE were separated into A,B,and C groups.Methylprednisolone was given 80 mg,VD.,b.i.d. in A and B groups.After 4 days,8 mg of methylprednisolone table was given,P.O.,b.i.d.for 5 days in A group,10 days in B group.16 mg of methylprednisolone table was given,P.O.,b.i.d.from 1st to 14 th day.The antibiotics,bronchodilators,and apophlegmatisant were given routinely.Result:The symptomatic score,FEV 1,FEV 1%,PaO\-2 and PaCO\-2 improved contrasting to pre-treatment.However three groups was no significant difference.The FVC increased markedly in A and B group at the middle and end of treatment.The improved rates of A,B,and C group were 51.5%,48.4%,and 39.4% respectively.The improvement of only cough was faster in A and B group than in C group though the effect of symptoms and signs at 2 nd after treatment in A and B group.The clinical cost was 3723.3 Yuan in A group,markedly less than 5494 Yuan in B group and 5041.1 Yuan in C group.Conclusion:The method of methylprednisolone sequential therapy for 9 days was worth to be extended because of the similar effect among methylprednisolone sequential therapy for 9 days,methylprednisolone sequential therapy for 14 days,and oral administration 14 days,faster effect,and less clinical cost.