Apoptotic Vesicles as Tumor Vaccine

小泡 细胞外小泡 化学 病毒学 医学 癌症研究 细胞生物学 生物 生物化学 膜
作者
Sophie K. Horrevorts,Juan Jesús García-Vallejo,Sandra J. van Vliet,Arjan A. van de Loosdrecht,Yvette van Kooyk,Tanja D. de Gruijl
出处
期刊:Immunotherapy [Future Medicine]
卷期号:8 (1): 5-8 被引量:3
标识
DOI:10.2217/imt.15.96
摘要

ImmunotherapyVol. 8, No. 1 EditorialApoptotic vesicles as tumor vaccineSophie K Horrevorts, Juan J Garcia-Vallejo, Sandra J van Vliet, Arjan A van de Loosdrecht, Yvette van Kooyk & Tanja D de GruijlSophie K Horrevorts Department of Molecular Cell Biology & Immunology, VU University Medical Center, Amsterdam, The Netherlands, Juan J Garcia-Vallejo Department of Molecular Cell Biology & Immunology, VU University Medical Center, Amsterdam, The Netherlands, Sandra J van Vliet Department of Molecular Cell Biology & Immunology, VU University Medical Center, Amsterdam, The Netherlands, Arjan A van de Loosdrecht Department of Hematology, VU University Medical Center, Amsterdam, The Netherlands, Yvette van Kooyk Department of Molecular Cell Biology & Immunology, VU University Medical Center, Amsterdam, The Netherlands & Tanja D de Gruijl*Author for correspondence: E-mail Address: TD.deGruijl@vumc.nl Medical Oncology, VU University Medical Center, Amsterdam, The NetherlandsPublished Online:7 Dec 2015https://doi.org/10.2217/imt.15.96AboutSectionsView ArticleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinkedInReddit View articleKeywords: antigensapoptosiscancer treatmentvaccinevesiclesReferences1 Kenter GG, Welters MJP, Valentijn ARPM et al. Vaccination against HPV-16 oncoproteins for vulvar intraepithelial neoplasia. N. Engl. J. Med. 361, 1838–1847 (2009).Crossref, Medline, CAS, Google Scholar2 Gilboa E. The makings of a tumor rejection antigen. Immunity 11, 263–270 (1999).Crossref, Medline, CAS, Google Scholar3 Rosenberg SA, Yang JC, Sherry RM et al. Durable complete responses in heavily pretreated patients with metastatic melanoma using T-cell transfer immunotherapy. Clin. Cancer Res. 17, 4550–4558 (2011).Crossref, Medline, CAS, Google Scholar4 Le DT, Uram JN, Wang H et al. PD-1 blockade in tumors with mismatch-repair deficiency. N. Engl. J. Med. 372, 2509–2520 (2015).Crossref, Medline, CAS, Google Scholar5 Schumacher TN, Schreiber RD. Neoantigens in cancer immunotherapy. Science 348(6230), 69–74 (2015).Crossref, Medline, CAS, Google Scholar6 Lawrence MS, Stojanov P, Polak P et al. Mutational heterogeneity in cancer and the search for new cancer-associated genes. Nature 499, 214–218 (2013).Crossref, Medline, CAS, Google Scholar7 Kokhaei P, Choudhury A, Mahdian R et al. Apoptotic tumor cells are superior to tumor cell lysate, and tumor cell RNA in induction of autologous T cell response in B-CLL. Leuk. Off. J. Leuk. Soc. Am. Leuk. Res. Fund UK 18, 1810–1815 (2004).Crossref, Medline, CAS, Google Scholar8 Hayashi T, Hideshima T, Akiyama M et al. Ex vivo induction of multiple myeloma-specific cytotoxic T lymphocytes. Blood 102, 1435–1442 (2003).Crossref, Medline, CAS, Google Scholar9 Ruben JM, Van Den Ancker W, Bontkes HJ et al. Apoptotic blebs from leukemic cells as a preferred source of tumor-associated antigen for dendritic cell-based vaccines. Cancer Immunol. Immunother. 63, 335–345 (2014).Crossref, Medline, CAS, Google Scholar10 Ruben JM, Bontkes HJ, Westers TM et al. In situ loading of skin dendritic cells with apoptotic bleb-derived antigens for the induction of tumor-directed immunity. OncoImmunology 4, 1–10 (2014).Google Scholar11 Yáñez-Mó M, Siljander PR, Andreu Z et al. Biological properties of extracellular vesicles and their physiological functions. J. Extracell. Vesicles 4, 1–60 (2015).Crossref, Google Scholar12 Théry C, Ostrowski M, Segura E. Membrane vesicles as conveyors of immune responses. Nat. Rev. Immunol. 9, 581–593 (2009).Crossref, Medline, CAS, Google Scholar13 Kalra H, Simpson RJ, Ji H et al. Vesiclepedia: a compendium for extracellular vesicles with continuous community annotation. PLoS Biol. 10, 8–12 (2012).Crossref, Google Scholar14 Fransen JH, Hilbrands LB, Ruben J et al. Mouse dendritic cells matured by ingestion of apoptotic blebs induce T cells to produce interleukin-17. Arthritis Rheum. 60, 2304–2313 (2009).Crossref, Medline, CAS, Google Scholar15 Liu K, Iyoda T, Saternus M, Kimura Y, Inaba K, Steinman RM. Immune tolerance after delivery of dying cells to dendritic cells in situ. J. Exp. Med. 196, 1091–1097 (2002).Crossref, Medline, CAS, Google Scholar16 Krysko DV, Garg AD, Kaczmarek A, Krysko O, Agostinis P, Vandenabeele P. Immunogenic cell death and DAMPs in cancer therapy. Nat. Rev. Cancer 12, 860–875 (2012).Crossref, Medline, CAS, Google Scholar17 Spisek R, Charalambous A, Mazumder A, Vesole DH, Jagannath S, Dhodapkar MV. Bortezomib enhances dendritic cell (DC)-mediated induction of immunity to human myeloma via exposure of cell surface heat shock protein 90 on dying tumor cells: therapeutic implications. Blood 109, 4839–4845 (2007).Crossref, Medline, CAS, Google Scholar18 Bilyy RO, Shkandina T, Tomin A et al. Macrophages discriminate glycosylation patterns of apoptotic cell-derived microparticles. J. Biol. Chem. 287, 496–503 (2012).Crossref, Medline, CAS, Google Scholar19 Meesmann HM, Fehr E-M, Kierschke S et al. Decrease of sialic acid residues as an eat-me signal on the surface of apoptotic lymphocytes. J. Cell Sci. 123, 3347–3356 (2010).Crossref, Medline, CAS, Google Scholar20 Fehres CM, Kalay H, Bruijns SCM et al. Cross-presentation through langerin and DC-SIGN targeting requires different formulations of glycan-modified antigens. J. Control. Release 203, 67–76 (2015).Crossref, Medline, CAS, Google ScholarFiguresReferencesRelatedDetailsCited ByInducing Endoplasmic Reticulum Stress to Expose Immunogens: A DNA Tetrahedron Nanoregulator for Enhanced Immunotherapy16 September 2020 | Advanced Functional Materials, Vol. 30, No. 48Expression levels of a gene signature in hiPSC associated with lung adenocarcinoma stem cells and its capability in eliciting specific antitumor immune‐response in a humanized mice model20 April 2020 | Thoracic Cancer, Vol. 11, No. 6 Vol. 8, No. 1 Follow us on social media for the latest updates Metrics Downloaded 138 times History Published online 7 December 2015 Published in print January 2016 Information© Future Medicine LtdKeywordsantigensapoptosiscancer treatmentvaccinevesiclesFinancial & competing interests disclosureSK Horrevorts was supported by ERC-Advanced-Glycotreat-339977. JJ Garcia-Vallejo was supported by ERC-Advanced-Glycotreat-339977and the CCA (Cancer center Amsterdam). SJ van Vliet was supported by the Dutch Cancer Society (KWF, VU2014–6779). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.No writing assistance was utilized in the production of this manuscript.PDF download
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
李爱国的应助被zzcres采纳,获得10
1秒前
打打的应助被伶俐一曲采纳,获得10
1秒前
2秒前
wmf完成签到 ,获得积分10
3秒前
3秒前
华仔的应助被xleizh采纳,获得10
4秒前
优秀大开完成签到,获得积分10
4秒前
shaymaa完成签到,获得积分10
4秒前
酷波er的应助被刘大壮采纳,获得10
5秒前
脑洞疼的应助被鳗鱼店员采纳,获得30
5秒前
我姓张发布了新的文献求助10
6秒前
iidodo发布了新的文献求助10
7秒前
7秒前
kangk完成签到,获得积分10
7秒前
华风发布了新的文献求助10
7秒前
田様的应助被冷酷的小之采纳,获得10
9秒前
9秒前
lotto的应助被哈哈采纳,获得20
9秒前
9秒前
CodeCraft的应助被Dale采纳,获得10
10秒前
洁净的三娘完成签到 ,获得积分20
10秒前
顾矜的应助被Dale采纳,获得10
10秒前
10秒前
慕青的应助被Dale采纳,获得10
10秒前
10秒前
10秒前
风趣过客完成签到,获得积分10
11秒前
慧宣完成签到,获得积分10
11秒前
睿O宝宝O完成签到 ,获得积分10
12秒前
有几颗荔枝完成签到,获得积分10
12秒前
13秒前
涤尘发布了新的文献求助10
13秒前
14秒前
14秒前
14秒前
15秒前
15秒前
15秒前
罗罗发布了新的文献求助10
15秒前
高分求助中
(应助此贴封号)【重要!!请各用户(尤其是新用户)详细阅读】【科研通的精品贴汇总】 10000
IRTSD: Open-Source Data and Toolset for Electromagnetic Transient Analysis of Disturbances and IBR Control Malfunctions in Transmission Systems 1000
Spec 401: Standards for Jet Fuel Facility and Equipment Commissioning and Flushing at Airports, 2026.1 (Original Issue) 1000
Spec 103: Standard for Jet Fuel Quality Control at Airports, Revision 2026.1 1000
A Consideration on Use of Material Grades for Hull Structural Members Based on Fracture Toughness(Second Report) 500
AI Disclosure in Annual Reports: Evolution, Determinants, and Capital Market Participants’ Perceptions 500
5th World Conference on Detergents: Reinventing the Industry : Opportunities and Challenges 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 纳米技术 计算机科学 工程类 有机化学 化学工程 生物化学 物理 复合材料 内科学 催化作用 光电子学 人工智能 细胞生物学 无机化学 物理化学 数学
热门帖子
关注 科研通微信公众号,转发送积分 8106912
求助须知:如何正确求助?哪些是违规求助? 9515244
关于积分的说明 21496865
捐赠科研通 7683076
什么是DOI,文献DOI怎么找? 3410186
关于科研通互助平台的介绍 2537626
邀请新用户注册赠送积分活动 2450086