信使核糖核酸
范围(计算机科学)
免疫疗法
接种疫苗
医学
多样性(控制论)
免疫系统
免疫学
计算生物学
生物
计算机科学
人工智能
生物化学
基因
程序设计语言
作者
Yasmin Granot-Matok,Edo Kon,Niels Dammes,Gilad Mechtinger,Dan Peer
标识
DOI:10.1016/j.jconrel.2019.05.032
摘要
In the past few years mRNA molecules have become an attractive class of new drugs with numerous opportunities. mRNA therapeutics holds great potential for the treatment of a variety of diseases and is an emerging field both in academia and in the pharma industry. Among the various mRNA-based therapeutic approaches, immunotherapy is one of the pioneering and most advanced therapy to date. Immune cells manipulation using mRNA is commonly used for vaccination purposes, but its potential is much broader. In this review, we discuss the promise of mRNA delivery to leukocytes. We aim to provide an overview of the main progress in this field, as well as the challenges in expanding the scope of mRNA therapy for different therapeutic applications. We also discuss the main technological developments for overcoming mRNA therapy limitations, including mRNA rational design and delivery platforms.
科研通智能强力驱动
Strongly Powered by AbleSci AI