The genus Hyptis (family Lamiaceae) is known mainly for the essential oils isolated from the aerial parts of several species.Less known are the diterpenoids, extracted from a limited number of species.In consideration of the interest for the structures of this class of compounds, largely occurring in the whole Lamiaceae family, the present paper means to review and update their chemistry.Also the use of many species of Hyptis in folk-medicine is reported.