[Lycorine inhibits the proliferation and promotes apoptosis of SGC-7901 gastric cancer cells by downregulating expression of cyclin D1].

of 24 hours and 48 hours to gastric cancer cells treated with lycorine was (20.85±2.36) μmol/L and (13.29±1.28) μmol/L, respectively. The cell cycle was arrested in G0/G1 phase, the apoptosis rate of cells increased, and the level of cyclin D1 mRNA and protein decreased significantly 48 hours after the treatment with 13 μmol/L lycorine. Conclusion Lycorine can inhibit the proliferation of SGC-7901 gastric cancer cells, induce cell cycle arrest in G0/G1 phase and promote cell apoptosis. The mechanism may be related to the down-regulation of cyclin D1 expression.