Fluorescent Polystyrene Latex Nanoparticles for NIR-II <i>in vivo</i> Imaging

In this study, tissue-penetrable near infrared (NIR)-II fluorescent polystyrene latex nanoparticles (NIR-PSt NPs) were designed and prepared as deep tissue in vivo imaging probes. An NIR-II fluorescent dye was successfully loaded into PSt NPs. The resulting NIR-PSt NPs showed strong NIR-II (1100 nm) emission in an aqueous environment. In addition, in vivo imaging of live mice was successfully performed using these NIR-PSt NPs. The prepared NIR-PSt NPs exhibited remarkable properties for in vivo fluorescence imaging.