It was found that the leaf plate of the Sultan cotton variety, which is grown in the conditions of weakly saline, moderately saline and non-saline soils of Andijan region,decreases as the level of soil salinity increases. UzDEF and FanDEF defoliants are applied to cotton at a rate of 5.0-6.0-7.0 l / ha compared to Liquid XMD 8.0 l / ha, in a weakly saline area - 6.0-7.0 l / ha, in moderately saline - 5.0- Defoliants were found to be more effective at 6.0 l / ha and 7.0 l / ha in the unsalted area.