NIR‐Responsive Fe3O4@MSN@PPy‐PVP Nanoparticles as the Nano‐Enzyme for Potential Tumor Therapy

Abstract Among various kinds of photothermal conversion materials, polypyrrole (PPy) has attracted ever‐increasing attention because of its good biocompatibility and excellent near‐infrared light response property. In this research, the core‐shell nanoparticles with magnetic Fe 3 O 4 as the core and mesoporous silica (MSN) as the shell were prepared, the resulted Fe 3 O 4 @MSN nanoparticles were then surface coated with a layer of PPy and further modified with polyvinylpyrrolidone (PVP) to gain colloidal stability. The Fe 2+ in Fe 3 O 4 can catalyze the decomposition of H 2 O 2 in tumor cells to produce cytotoxic hydroxyl radicals, thus realizing the tumor chemodynamic therapy. Meanwhile, the MSN layer gives the nanoparticles a higher drug loading capacity of chemotherapeutics (doxorubicin, DOX). Therefore, the prepared Fe 3 O 4 @MSN@PPy‐PVP nanoparticles not only have good biocompatibility, magnetism and colloidal stability but also can realize the combined tumor photothermal, chemo, and chemodynamic therapy. This study demonstrates the rational design of multifunctional nanoplatforms for biomedical applications.