化学
吲唑
碳化物
铑
酒
芳基
催化作用
表面改性
烷基
选择性
烷基化
组合化学
梅尔德姆酸
功能群
药物化学
有机化学
聚合物
物理化学
作者
Chengye Yuan,Dongdong Chen,Changduo Pan,Jin‐Tao Yu
标识
DOI:10.1016/j.jorganchem.2021.122009
摘要
A rhodium-catalyzed alcohol-mediated ortho-functionalization of 2-aryl-2H-indazoles through sequential C-H activation and carbenoid insertion with diazotized Meldrum's acid was developed. Using the 2H-indazole as the directing group and alcohol as the alkyl source, a series of ortho-alkylated aryl-2H-indazoles were obtained over a wide structural scope with high site-selectivity and excellent functional-group tolerance.
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