生殖系
基因组
生物
计算生物学
注释
内源性逆转录病毒
DNA
遗传学
DNA测序
病毒学
基因
作者
Umberto Palatini,Elisa Pischedda,Mariangela Bonizzoni
标识
DOI:10.1007/978-1-0716-2380-0_18
摘要
The transfer of genetic material between viruses and eukaryotic cells is pervasive. Somatic integrations of DNA viruses and retroviruses have been linked to persistent viral infection and genotoxic effects. Integrations into germline cells, referred to as Endogenous Viral Elements (EVEs), can be co-opted for host functions. Besides DNA viruses and retroviruses, EVEs can also derive from nonretroviral RNA viruses, which have often been observed in piRNA clusters. Here, we describe a bioinformatic framework to annotate EVEs in a genome assembly, study their widespread occurrence and polymorphism and identify sample-specific viral integrations using whole genome sequencing data.
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