加巴能
神经科学
γ-氨基丁酸受体
抑制性突触后电位
原发性震颤
神经药理学
γ-氨基丁酸
神经递质
神经解剖学
药理学
医学
生物
受体
心理学
中枢神经系统
内科学
出处
期刊:Elsevier eBooks
[Elsevier]
日期:2022-01-01
卷期号:: 317-334
被引量:2
标识
DOI:10.1016/bs.irn.2022.02.007
摘要
γ-Aminobutyric acid (GABA) is the most prevalent inhibitory CNS neurotransmitter. Activating GABA-A receptors hyperpolarizes cells via Cl- influx, which inhibits action potentials. Although the exact pathophysiologies of tremor are incompletely understood, proposed neuroanatomy extensively implicates GABA pathways. Pathological studies and imaging studies also show GABA abnormalities in patients with ET. Most importantly, medications that activate GABA-A receptors, such as primidone, often improve tremor. Ongoing clinical trials and physiology research should further refine potential future GABAergic targets and treatments, which are currently the most promising targets for pharmacological intervention.
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