EZH2型
甲状腺
甲状腺癌
免疫组织化学
癌症
医学
增殖标记
癌症研究
甲状腺癌
肿瘤科
内科学
病理
生物
基因表达
基因
遗传学
作者
Katsuhiko Masudo,Nobuyasu Suganuma,Hirotaka Nakayama,Takashi Oshima,Yasushi Rino,H. Iwasaki,Kenichi Matsuzu,Kiminori Sugino,Koichi Ito,Tetsuo Kondo,Yoshiyasu Nakamura,Masaharu Yoshihara,Munetaka Masuda,Yohei Miyagi
出处
期刊:in Vivo
[Anticancer Research USA Inc.]
日期:2018-01-02
卷期号:32 (1)
被引量:17
标识
DOI:10.21873/invivo.11200
摘要
Enhancer of zeste homolog 2 (EZH2) is a member of the polycomb group of genes, which are key factors in the regulation of cell proliferation and differentiation. EZH2 is overexpressed in many malignancies. We analyzed EZH2 protein expression levels in different histological subtypes of thyroid cancer to examine its utility as a prognostic factor.We examined EZH2 protein expression by immunohistochemistry in tissue samples from 67 cases of poorly differentiated (PDTC) and 48 cases of anaplastic thyroid carcinoma (ATC), and in samples of adjacent normal and differentiated thyroid carcinoma (DTC). We examined differences in expression of EZH2 among various histological types of thyroid cancer, and the relationship between EZH2 expression and patient outcome.EZH2 protein was expressed in PDTC and ATC, but not in normal thyroid gland or DTC. EZH-positivity increased in the order of DTC, PDTC, and ATC (p<0.01). Higher EZH2 expression correlated with poorer survival in PDTC (p=0.004), and a similar but non-significant trend was observed in ATC (p=0.166). Multivariate analysis identified EZH2 as an independent prognostic factor similar to metastatic status in the Japanese Society of Thyroid Surgery (JSTS) classification of PDTC.EZH2 overexpression is associated with malignant potential in thyroid cancer, and may thus be a useful prognostic marker of aggressive thyroid cancer.
科研通智能强力驱动
Strongly Powered by AbleSci AI