神经炎症
炎症
伤害感受器
慢性疼痛
医学
免疫系统
发病机制
神经科学
伤害
受体
小胶质细胞
免疫学
生物
内科学
作者
Ru‐Rong Ji,Alexander Chamessian,Yu‐Qiu Zhang
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2016-11-04
卷期号:354 (6312): 572-577
被引量:875
标识
DOI:10.1126/science.aaf8924
摘要
Acute pain is protective and a cardinal feature of inflammation. Chronic pain after arthritis, nerve injury, cancer, and chemotherapy is associated with chronic neuroinflammation, a local inflammation in the peripheral or central nervous system. Accumulating evidence suggests that non-neuronal cells such as immune cells, glial cells, keratinocytes, cancer cells, and stem cells play active roles in the pathogenesis and resolution of pain. We review how non-neuronal cells interact with nociceptive neurons by secreting neuroactive signaling molecules that modulate pain. Recent studies also suggest that bacterial infections regulate pain through direct actions on sensory neurons, and specific receptors are present in nociceptors to detect danger signals from infections. We also discuss new therapeutic strategies to control neuroinflammation for the prevention and treatment of chronic pain.
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