1.4 Copper-Catalyzed C—H Functionalization via Radicals

Abstract The direct functionalization of C—H bonds is highly attractive due to its efficiency for converting simple molecules into a wide range of valuable organic compounds. Among available strategies, radical C—H functionalization via hydrogen-atom transfer (HAT) represents one of the most powerful approaches and allows a unique profile of reactivity and selectivity. In this review, copper-catalyzed C—H functionalizations via radicals are summarized, including C—H cyanation, arylation, alkynylation, fluoroalkylation, amination, and oxygenation. It is worth noting that the combination of chiral ligands and chiral phosphoric acids with copper catalysis enables the enantioselective functionalization of radicals.