Enhancing Detection of Per- and Polyfluoroalkyl Substances via Pore-Microenvironment-Engineered Hierarchical Porous Covalent Organic Frameworks-Based Probe Nanoelectrospray Ionization Mass Spectrometry

of 0.999-0.9998). The method developed has been successfully applied to real samples (tap water, lake water, spring water, ocean water, and blood) with satisfactory recoveries (75.1-112.9%). All of these features demonstrated that pore-microenvironment engineering of COFs-SPME probes is a promising and effective strategy for the rapid, selective and ultrasensitive determination of PFASs in real applications.