微流控
药物输送
气泡
生物医学工程
PLGA公司
纳米技术
材料科学
毒品携带者
体内
药品
化学
药理学
医学
纳米颗粒
计算机科学
生物
生物技术
并行计算
作者
Xiang Chen,Danna Liang,Weijian Sun,Xin Shou,Luoran Shang,Xian Shen
标识
DOI:10.1016/j.cej.2023.141428
摘要
Microcapsules are promising drug carriers for disease treatment. Specifically, for drug delivery in the stomach, a key point is to enable retention of the carriers regardless of gastric emptying and peristalsis. Here, we designed novel drug-loaded bubble microcapsules, which were prepared by microfluidic technology and used for oral drug delivery. The bubble microcapsules were composed of a PLGA shell and a bubble core, which was derived from osmotic-triggered cavitation. The PLGA shell ensured efficient drug encapsulation and sustained release; the bubble core enabled retention of the microcapsules in the stomach and thus facilitated long-term treatment. Based on this, we confirmed anti-tumor effects of drug-loaded bubble microcapsules in vivo and in vitro. The drug-loaded bubble microcapsules significantly inhibited the growth and metastasis of tumors. These results suggest that the suspended bubble microcapsules can be used as an ideal drug release platform for cancer therapy. It is foreseeable that the suspension bubble microcapsules prepared by this method would have broader application prospects as oral delivery vehicles for the treatment of gastrointestinal diseases.
科研通智能强力驱动
Strongly Powered by AbleSci AI