A single mode microstructured polymer optical fiber has been designed and analysed based on finite element method (FEM). The design parameters of proposed microstructured polymer optical fiber structure have been optimized to obtain single mode operation along with mode area of 895 μm2. The differential loss between fundamental and higher order modes of structure have been obtained very large (~103) with negligible loss of fundamental mode. The proposed structure is effectively single mode at 632.8 nm wavelength after the short distance 1.65 m with very low loss of guiding mode. The proposed structure is applicable for high power delivery devices.