胰腺癌
细胞周期
医学
信号转导
细胞周期进展
癌症研究
细胞凋亡
细胞
细胞生长
癌症
细胞生物学
生物信息学
神经科学
生物
内科学
遗传学
作者
Lucas P. Nacusi,Robert J. Sheaff
出处
期刊:Pancreatology
[Elsevier]
日期:2007-09-01
卷期号:7 (4): 373-377
被引量:3
摘要
Disrupted cell cycle machinery is commonly thought to result in loss of proliferative control. Standard therapies target these rapidly dividing cells, yet they are ineffective against pancreatic cancer, suggesting that its development and/or progression might deviate from standard paradigms. Supposedly essential cell cycle components are actually dispensable in mice, and accumulating evidence indicates that they play more diverse roles during apoptosis, signal transduction, and cell migration. A better understanding of how pancreatic cancer cells proliferate and the contribution of disrupted cell cycle machinery would provide much needed opportunities for developing new diagnostic and therapeutic options to improve patient outcome.
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