腺苷
G蛋白偶联受体
化学
腺苷A2A受体
药物发现
腺苷受体
药理学
受体
兴奋剂
药品
生物化学
医学
作者
Manuel de Lera Ruiz,Yeon‐Hee Lim,Junying Zheng
摘要
The adenosine A2A receptor is a G-protein-coupled receptor (GPCR) that has been extensively studied during the past few decades because it offers numerous possibilities for therapeutic applications. Herein we describe adenosine A2A receptor distribution, signaling pathways, pharmacology, and molecular structure, followed by a summary and SAR discussion of the most relevant series of adenosine A2A agonists and antagonists. This review also provides an update of the A2A ligands that are undergoing or have undergone clinical studies, including the two currently marketed agonists adenosine and regadenoson.
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