白细胞介素15
生物
细胞毒性T细胞
状态5
干扰素
免疫系统
细胞生物学
启动(农业)
获得性免疫系统
CD8型
先天免疫系统
免疫学
细胞因子
白细胞介素12
信号转导
白细胞介素
体外
发芽
植物
生物化学
作者
Mikkel L. Hansen,Anders Woetmann,Thorbjørn Krejsgaard,Katharina Kopp,Rolf Søkilde,Thomas Litman,Per Th Straten,Carsten Geisler,Mariusz A. Wasik,Niels Ødum,Kathrine Krageskov Eriksen
标识
DOI:10.1016/j.molimm.2011.07.008
摘要
Recently it has become clear that interferon (IFN)-α, a type I interferon produced rapidly in response to infection, not only plays a key role in innate immunity, but also promotes adaptive immune responses by influencing the production or function of other cytokines. During infections IFN-α fosters the production of IL-15, which plays a pivotal role in the development, survival and function of NK cells and recruitment and activation of T cells. Since these two cytokines exert overlapping functions during infections, this investigation was undertaken to study the priming effect of IFN-α on the effect of IL-15 on human T and NK cells. We show that IFN-α induces an increased expression of IL-15Rα in human activated peripheral T cells, and in CD8+ and CD4+ T-cell lines. Functionally, the IFN-α-enhanced IL-15Rα expression resulted in an enhanced IL-15-mediated phosphorylation of STAT5 and STAT3 followed by a further increase in IL-15Rα expression. Moreover, IFN-α significantly increased the IL-15-induced cytotoxic activity of freshly isolated T and NK cells. Taken together, our data show that IFN-α boosts signaling and functional effects of IL-15, at least in part by fostering the increased IL-15R expression, thus add new facet to the emerging role of IFN-α as an important primer of adaptive immune responses.
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