The appliance of lentivirus vector in cancer theray

Vector is a transfer tool inserting interest gene to host cell in order to duplicate or expression. It can be classified as two categories: nonvirus vector or virus vector. The latter including retrovirus,adenvirus,adenvirus-associated virus and so on, is the main vector using in the study of gene therapy , because it could be so efficient to transfer the gene in vitro or in vivo. Lentivirus vector,an kind of retrovirus vector, has been paid much more attention in recent years. It could become an idea vector because it has following characteristic:infecting non-dividing cell, interest gene integrating the genomic and expressing long term, little immunologic reaction etc. In this article we reviewed the construction of lentivirus vector based on the HIV-1,optimizing in structure and its appliance in cancer therapy.