Synthesis of Piperazinyl Formamide Derivatives

N-Boc-Piperazinyl formamides were synthesized in one-pot procedure from aryl amines,triphosgene and N-boc-piperazine at-5℃.The protective group of boc was eliminated to give piperazinyl formamide derivatives in a solution of HCl in dioxane.The effect of the concentration of HCl was discussed.