医学
相伴的
激素疗法
雌激素
更年期
激素替代疗法(女性对男性)
静脉血栓栓塞
内科学
绝经后妇女
流行病学
激素
妇科
血栓形成
乳腺癌
癌症
睾酮(贴片)
作者
Valérie Olié,Marianne Canonico,Pierre‐Yves Scarabin
标识
DOI:10.1016/s0049-3848(11)70008-1
摘要
Hormone therapy (HT) is the most effective treatment to counteract menopauserelated symptoms. Because venous thromboembolism (VTE) is the main harmful effect of HT among young postmenopausal women, reducing VTE risk appears to be a relevant strategy to improve the benefit/risk profile of HT among postmenopausal women.This article is a review of recent findings regarding the VTE risk among women using HT.Recent data confirmed the safety of the transdermal route of estrogens administration in postmenopausal women requiring treatment. In addition, epidemiological data showed that use of concomitant progestins could increase VTE risk compared with progesterone use. Finally, results of a meta-analysis showed that the VTE risk increased with doses of oral estrogens.The route of estrogen administration, the type of concomitant progestogens and the dose of estrogens are three important determinants of the thrombotic risk among postmenopausal women using HT.
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