Neurodegenerative diseases are advancing conditions marked by loss of neurons and neural function, resulting in cognitive and motor difficulties. Present therapies offers symptomatic relief but do not stop the advancement of the disease. Currently, there are no treatment that can reverse these diseases. The latest developments in microfluidic chip technologies, such as in-vitro brainon-chip and in-vivo-like chip models, provide groundbreaking platforms for investigating. Chips designed for managing neurodegenerative diseases are sophisticated instruments that replicate the brain's environment in laboratory settings. In-vitro chips mimic the brain's cellular microenvironment, allowing for thorough studies of neurodegeneration, neuroinflammation, and blood-brain barrier dynamics. In-vivo chips replicate physiological aspects like vascular flow and multicellular interactions, connecting animal models to human clinical outcomes. These chipbased systems offer promising advancements for personalized medicine and creation of effective treatments for neurodegenerative diseases. Through targeted electrical stimulation and biomodulation, neural implants are transforming the treatment of neurodegenerative diseases by modulating neural activity and fostering functional recovery. These technologies offer the potential to convert neurorehabilitation into a tailored, dynamic process that tackles the progressive neural dysfunction typical of neurodegenerative diseases. Challenges persist in enhancing the biocompatibility of implants, reducing inflammatory reactions, and guaranteeing their long-term effectiveness and safety.