化学
电催化剂
对映选择合成
立体中心
烯烃纤维
催化作用
组合化学
阳极
阴极
胺气处理
电解
电极
电化学
有机化学
物理化学
电解质
作者
Cheng Huang,Yongsheng Tao,Xiaodan Cao,Cong Zhou,Qingquan Lu
摘要
Asymmetric electrocatalysis offers exciting new strategies for the synthesis of chiral molecules through novel reaction pathways. However, simultaneous activation of reactants on both electrodes via asymmetric paired electrolysis, which is more energy efficient and economic than single half-electrode synthesis, remains a formidable challenge. Herein, an asymmetric olefin-sulfonylimine coupling via paired electrocatalysis is presented for the first time. In this protocol, Co-catalyzed hydrogen atom transfer on the anode and Ni-catalyzed sulfonylimine reduction on the cathode were seamlessly cross-coupled. The new catalytic system enables the formation of chiral amine products bearing a tetrasubstituted carbon stereocenter with a high enantioselectivity (up to 96% ee).
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