医学
子宫内膜癌
肿瘤科
内科学
指南
辅助治疗
癌症
妇科
妇科肿瘤学
阶段(地层学)
病理
古生物学
生物
作者
Shogo Shigeta,Yosuke Konno,Yoshito Terai,Tohru Morisada,Hideki Tokunaga,Tsukasa Baba,Yoichi Kobayashi,Satoru Nagase
出处
期刊:Japanese Journal of Clinical Oncology
[Oxford University Press]
日期:2023-10-11
摘要
In association with an update of the Japan Society of Gynecologic Oncology clinical practice guidelines for endometrial cancer in 2023, a systematic review was conducted about the therapeutic benefit of adjuvant therapy on patients with early-stage endometrial carcinoma, who presented positive peritoneal cytology (PPC) without the risk factors for recurrence. The systematic review only included two eligible retrospective studies. Both studies included patients with risk factors for recurrence. A nationwide study in the United States reported that adjuvant chemotherapy was associated with the reduced risk of death among patients with stages I-II endometrial cancer with PPC by multivariate, propensity score-adjusted analysis. Another single-center study in Japan reported no association between adjuvant chemotherapy and relapse-free survival among patients with stage IA endometrial cancer by univariate analysis. This systematic review identified that evidence was limited with conflicting results. Continuous evaluation is warranted to address this clinical question.
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