神经刺激
重性抑郁障碍
背外侧前额叶皮质
神经科学
扣带回前部
神经调节
功能磁共振成像
前额叶皮质
心理学
生物标志物
静息状态功能磁共振成像
萧条(经济学)
功能连接
大脑活动与冥想
医学
认知
生物
脑电图
刺激
生物化学
宏观经济学
经济
作者
Anish Mitra,Marcus E. Raichle,Andrew Geoly,Ian H. Kratter,Nolan Williams
标识
DOI:10.1073/pnas.2218958120
摘要
Major depressive disorder (MDD) is widely hypothesized to result from disordered communication across brain-wide networks. Yet, prior resting-state-functional MRI (rs-fMRI) studies of MDD have studied zero-lag temporal synchrony (functional connectivity) in brain activity absent directional information. We utilize the recent discovery of stereotyped brain-wide directed signaling patterns in humans to investigate the relationship between directed rs-fMRI activity, MDD, and treatment response to FDA-approved neurostimulation paradigm termed Stanford neuromodulation therapy (SNT). We find that SNT over the left dorsolateral prefrontal cortex (DLPFC) induces directed signaling shifts in the left DLPFC and bilateral anterior cingulate cortex (ACC). Directional signaling shifts in the ACC, but not the DLPFC, predict improvement in depression symptoms, and moreover, pretreatment ACC signaling predicts both depression severity and the likelihood of SNT treatment response. Taken together, our findings suggest that ACC-based directed signaling patterns in rs-fMRI are a potential biomarker of MDD.
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