Ultrasound‐Triggered Dinuclear Iridium Sonosensitizer Activates Paclitaxel Prodrug for Synergistic Sonodynamic‐Chemotherapy

-TK is effectively activated, addressing the critical bottleneck of tumor-specific prodrug activation. This synergistic sonodynamic-chemotherapy strategy achieves potent tumor eradication (95.8% inhibition) and stimulates a robust anti-tumor immune response, while significantly minimizing systemic toxicity associated with conventional PTX administration.