动脉炎
主动脉炎
免疫抑制
医学
病理
生物
内科学
主动脉
作者
Carole Vignals,Joseph Emmerich,Hugues Bégueret,Dea Garcia‐Hermoso,Guillaume Martin‐Blondel,A. Angoulvant,Damien Blez,Patrick Bruneval,Sophie Cassaing,Émilie Catherinot,P Cahen,Cécile Moluçon‐Chabrot,Carole Chevenet,Laurence Delhaès,L. Escaut,Marie Faruch,Frédéric Grenouillet,Fabrice Larosa,Lucie Limousin,Élisabeth Longchampt
标识
DOI:10.3201/eid3006.231409
摘要
Abstract Scedosporium spp. and Lomentospora prolificans are emerging non-Aspergillus filamentous fungi. The Scedosporiosis/lomentosporiosis Observational Study we previously conducted reported frequent fungal vascular involvement, including aortitis and peripheral arteritis. For this article, we reviewed 7 cases of Scedosporium spp. and L. prolificans arteritis from the Scedosporiosis/lomentosporiosis Observational Study and 13 cases from published literature. Underlying immunosuppression was reported in 70% (14/20) of case-patients, mainly those who had solid organ transplants (10/14). Osteoarticular localization of infection was observed in 50% (10/20) of cases; infections were frequently (7/10) contiguous with vascular infection sites. Scedosporium spp./Lomentospora prolificans infections were diagnosed in 9 of 20 patients ≈3 months after completing treatment for nonvascular scedosporiosis/lomentosporiosis. Aneurysms were found in 8/11 aortitis and 6/10 peripheral arteritis cases. Invasive fungal disease–related deaths were high (12/18 [67%]). The vascular tropism of Scedosporium spp. and L. prolificans indicates vascular imaging, such as computed tomography angiography, is needed to manage infections, especially for osteoarticular locations.
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