Enantioselective Cobalt-Catalyzed C–H Functionalization

Abstract Co-catalyzed C–H functionalization has received great attention due to the high earth abundance, low biotoxicity, and unique reactivity of cobalt; enantioselective control of these reactions has been a formidable challenge. Various efficient strategies have recently been developed for enantioselective Co-catalyzed C–H functionalization, but there is no topical review of this field. Herein, we give a detailed summary of this rapidly growing field, highlighting critical progress, current challenges, and future trends. 1 Introduction 2 Enantioselective C–H Functionalization via Low-Valent Co Catalysis 2.1 Chiral Diphosphines for Enantioselective Control 2.2 Chiral Monophosphines or N-Heterocyclic Carbenes for Enantioselective Control 3 Enantioselective C–H Functionalization via High-Valent Co Catalysis 3.1 Chiral Acids for Enantioselective Control 3.2 Chiral Cp Ligands for Enantioselective Control 4 Conclusions and Outlook